Calvarial Cleidocraniodysplasia-Like Defects With ENU-Induced Nell-1 Deficiency
نویسندگان
چکیده
منابع مشابه
Nell-1, a key Functional Mediator of Runx2, Partially Rescues Calvarial Defects in Runx2+/− Mice
Mesenchymal stem cell commitment to an osteoprogenitor lineage requires the activity of Runx2, a molecule implicated in the etiopathology of multiple congenital craniofacial anomalies. Through promoter analyses, we have recently identified a new direct transcriptional target of Runx2, Nell-1, a craniosynostosis (CS)-associated molecule with potent osteogenic properties. This study investigated ...
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متن کاملCraniosynostosis in transgenic mice overexpressing Nell-1.
Previously, we reported NELL-1 as a novel molecule overexpressed during premature cranial suture closure in patients with craniosynostosis (CS), one of the most common congenital craniofacial deformities. Here we describe the creation and analysis of transgenic mice overexpressing Nell-1. Nell-1 transgenic animals exhibited CS-like phenotypes that ranged from simple to compound synostoses. Hist...
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ژورنال
عنوان ژورنال: Journal of Craniofacial Surgery
سال: 2012
ISSN: 1049-2275
DOI: 10.1097/scs.0b013e318240c8c4